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The concomitant usage of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors may possibly lead to an increase in methadone plasma concentrations, which could trigger possibly deadly respiratory melancholy. Furthermore, discontinuation of concomitantly made use of cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers might also result